Amphiphilic Polyphenylene Dendron Conjugates for Surface Remodeling of Adenovirus 5
نویسندگان
چکیده
منابع مشابه
Polyphenylene dendrimers as scaffolds for shape-persistent multiple peptide conjugates.
The present work describes synthetic concepts for the coupling of peptides to polyphenylene dendrimers (PPDs). Novel functionalized cyclopentadienones have been synthesized whose Diels-Alder cycloaddition with various core molecules leads to polyphenylene dendrimers possessing (protected) amino or carboxyl groups. In addition, the resulting functionalized molecules exhibit the characteristic sh...
متن کاملEnhancement of surface ligand display on PLGA nanoparticles with amphiphilic ligand conjugates.
Biodegradable polymeric nanoparticles are widely recognized as efficacious drug delivery vehicles, yet the rational engineering of nanoparticle surfaces in order to improve biodistribution, reduce clearance, and/or improve targeting remains a significant challenge. We have previously demonstrated that an amphiphilic conjugate of avidin and palmitic acid can be used to modify poly(lactic-co-glyc...
متن کاملPhosphokinase Antibody Arrays on Dendron-Coated Surface
Monitoring protein phosphorylation at the cellular level is important to understand the intracellular signaling. Among the phosphoproteomics methods, phosphokinase antibody arrays have emerged as preferred tools to measure well-characterized phosphorylation in the intracellular signaling. Here, we present a dendron-coated phosphokinase antibody array (DPA) in which the antibodies are immobilize...
متن کاملAmphiphilic Diblock Copolymer Surface
10 11 Both visible and infrared (IR) spectroscopic ellipsometry have been employed to study the 12 structure of thin layers of bovine submaxillary mucin (BSM) adsorbed on poly(acrylic acid13 block-methyl methacrylate) (PAA-b-PMMA) copolymer and poly(methyl methacrylate) 14 surfaces at three pH values (3, 7 and 10). The adsorbed mucin layer on the copolymer surface 15 had the greatest thickness ...
متن کاملEffects of molecular geometry on the self-assembly of giant polymer-dendron conjugates in condensed state.
A series of giant polymer-dendron conjugates with a dendron head and a linear polymer tail were synthesized via"click" chemistry between azide-functionalized polystyrene (PS(N), N: degree-of-polymerization) and t-butyl protected, alkyne-functionalized second generation dendron (tD), followed by a deprotection process to generate a dendron termini possessing nine carboxylic acid groups. The mole...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2020
ISSN: 1433-7851,1521-3773
DOI: 10.1002/anie.201913708